Dihydroberberine SR 150 mg 60 Tablets

Dihydroberberine SR — Highly Bioavailable Berberine for Blood Sugar and Metabolic Support Without GI Upset

Endurance Products Dihydroberberine SR delivers 150mg of dihydroberberine (DHB) — a reduced, hydrogenated form of berberine with dramatically superior bioavailability — in the company's SmartMatrix™ sustained-release wax matrix tablet that releases the active compound gradually over 5–7 hours. Dihydroberberine is produced in the body as a metabolic intermediate during berberine absorption, and research has shown it to achieve plasma concentrations significantly higher than an equivalent dose of berberine, meaning a lower effective amount is needed to produce the same AMPK-activating metabolic effects.

This enhanced bioavailability also resolves the primary practical problem with standard berberine supplementation: the gastrointestinal distress (cramping, diarrhea, nausea) that a substantial proportion of patients experience with conventional berberine at therapeutic doses. Because dihydroberberine achieves therapeutic tissue concentrations at lower doses with more gradual absorption via the wax matrix, the GI burden is substantially reduced without sacrificing metabolic efficacy. The AMPK pathway that dihydroberberine activates is the master metabolic kinase that increases cellular glucose uptake, reduces hepatic glucose production, promotes fatty acid oxidation, and improves insulin sensitivity — the same pathway activated by metformin — making dihydroberberine one of the most mechanistically compelling botanical metabolic supplements available.

• Dihydroberberine 150mg per tablet — 5x more bioavailable than standard berberine
• SmartMatrix™ sustained release over 5–7 hours — reduced GI side effects
• AMPK activation — blood glucose, insulin sensitivity, lipid metabolism support
• 60 tablets; vegan, gluten-free

Take 1 tablet twice daily with food, or as directed by your healthcare provider.