HistDAO™ 60 Tablets

Diamine Oxidase (DAO) Enzyme Supplement for Histamine Intolerance and GI Histamine Support

HistDAO 60 Tablets by XYMOGEN is a diamine oxidase (DAO) enzyme supplement delivering 20,000 HDU of DAO enzyme per tablet — the primary enzyme responsible for breaking down dietary histamine in the gut before it is absorbed into circulation. This 30-day supply is designed for adults with histamine intolerance who experience symptoms after consuming high-histamine foods.

How DAO Enzyme Deficiency Causes Histamine Intolerance

Histamine is found in high amounts in fermented foods, aged cheeses, wine, processed meats, and leftovers. In individuals with sufficient DAO activity, dietary histamine is degraded in the gut before absorption. When DAO activity is low — due to genetic variants, intestinal damage, medications, or nutrient deficiencies — dietary histamine passes through and reaches circulation, triggering symptoms including headaches, flushing, nasal congestion, GI distress, and skin reactions.

Key Features of This DAO Enzyme Supplement

• 20,000 HDU diamine oxidase per tablet — clinically meaningful enzyme activity
• Degrades dietary histamine in the gut before absorption
• 60 tablets — 30-day supply at 2 per day (before meals)
• Supports histamine intolerance symptom reduction after high-histamine meals
• Complements low-histamine dietary strategies

Who This Is For

This DAO enzyme supplement is ideal for adults with confirmed or suspected histamine intolerance — particularly those with recurring GI symptoms, headaches, flushing, or nasal congestion after eating fermented, aged, or high-histamine foods.

How to Use

Take 1–2 tablets before histamine-containing meals, or as directed by your healthcare provider.